A cell's glycocalyx connects the inside of a cell with the outside, thus being involved in numerous biological processes including cell–cell communication. 1 Conjugated in various forms, such as in glycoproteins and glycolipids for example, they make up a thick layer, called glycocalyx, 2 which covers all cell surfaces. Introduction Carbohydrates, beside nucleic acids and proteins, constitute a class of biopolymers that govern the molecular complexity and individual diversity of organisms. In 20 Thisbe Lindhorst serves as elected president of the German Chemical Society (GDCh).
She is the author of the text book “Essentials in Carbohydrate Chemistry and Biochemistry”. Her research is focused on glycomimetics synthesis, glycoarrays, and the biological role of the glycocalyx.
#BOC BORN CONCEPTS FULL#
Thisbe Lindhorst started her own independent research in the field of the glycosciences at the University of Hamburg and was appointed full professor at Christiana Albertina University of Kiel in 2000. Thiem at the University of Hamburg and performed a postdoctoral training with Prof. Thisbe Lindhorst studied chemistry at the Universities of München and Münster. In 2014 he was a researcher in the Mallet group and in 2015 joined the Lindhorst group at Christiana Albertina University of Kiel with the aim to start an independent carrier. Jean-Marie Beau at Université Paris-Sud as a postdoctoral fellow, working on chitooligomers. The same year, he joined the group of Prof. He worked on the synthesis of functional bioactive oligosaccharides, especially chondroitin sulfate analogues.
He received his PhD degree in organic chemistry at the University Pierre et Marie Curie, Paris, in 2011 under the supervision of Dr Jean-Maurice Mallet. He obtained an engineering degree in chemistry in 2006 at the Ecole Nationale Supérieure des Ingénieurs en Arts Chimiques et Technologiques in Toulouse. Guillaume Despras was born in Ajaccio, France, in 1982. Lindhorst, which is focused on the synthesis of photoswitchable homo- and heteroglycoclusters. Currently he is finishing his PhD thesis in the research group of Prof. During his diploma thesis he dealt with the synthesis of trivalent cluster glycosides for the investigation of carbohydrate recognition on surfaces. He graduated from Christiana Albertina University of Kiel in chemistry. We are discussing primary, secondary and tertiary structural aspects including approaches to organize multivalency.Ĭhristian Müller was born in Bad Oldesloe, Germany, in 1984.
This review is focused on smaller multivalent structures such as glycoclusters emphasizing carbohydrate-centered and heteromultivalent glycoconjugates. Many multivalent glycoconjugates have therefore been synthesized to study multivalency effects operative in glycobiology. One of the supramolecular principles underlying and regulating carbohydrate recognition is multivalency. The interactions of cell surface carbohydrates as well as of soluble glycoconjugates with their receptor proteins rule fundamental processes in cell biology.
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